Mouse xenograft models vs GEM models for human cancer therapeutics

Mouse xenograft models vs GEM models for human cancer therapeutics.

The use of GEM models for experimental cancer therapeutics.

1Rm140B, Cambridge Research Institute (CRUK), Robinson Way, Cambridge CB2 0RE, UK *Author for correspondence (e-mail: [email protected]) GEM models that accurately model human cancer at both the molecular and phenotypic levels are new tools that are available for experimental therapeutic studies Introduction The proposal of new therapeutic strategies for cancer patients has been great...

I-54: New Models for Human and Mouse Genetic

The possibility to reprogram somatic human cells will greatly and deeply change genetic approach and allow the development of new tools to study genetics diseases. Indeed, our ability to study human genetic diseases suffers from the lack of valid in vitro models. The latter should (i) be originating from human primary cells, (ii) be able to self-renew for a long time and (iii) be able to differ...

Mouse models of human cancer.

The Helmholtz Alliance Preclinical Comprehensive Cancer Center (PCCC; www.helmholtz-pccc.de) hosted the "1st International Kloster Seeon Meeting on Mouse Models of Human Cancer" in the Seeon monastery (Germany) from March 8 to 11, 2014. The meeting focused on the development and application of novel mouse models in tumor research and high-throughput technologies to overcome one of the most crit...

In vivo models for experimental therapeutics relevant to human cancer.

The Developmental Therapeutics Program (DTP) of the National Cancer Institute (NCI) sponsored a symposium on In vivo Models for Experimental Therapeutics Relevant to Human Cancer on April 1, 2004, in Frederick, Maryland. About 50 scientists attended, with 8 invited speakers coming from Germany, the Netherlands, and various institutions in the United States. The meeting focused primarily on nove...